ANTITUBERCULOUS EFFECTS OF CERTAIN SURFACE-ACTIVE POLYOXYETHYLENE ETHERS

Triphosphatase of Cerebral Microsomes by Surface-Active Agents, especially Polyoxyethylene Ethers: Actions of Phospholipases and a Neuraminidase

sisting of a short length of 8 mm. diam. Visking tubing knotted to form a bag, the open end being secured to a piece of glass tubing by a close-fitting rubber stopper fitted to a test tube with a side arm. The bag, after being washed with distilled water, was equilibrated with a drop of the sample solution; this drop was discarded before evacuating the tube and introducing the rest of the sampl...

Micellization of sodium dodecyl sulfate and polyoxyethylene dodecyl ethers in solution

The effect of polyoxyethylene type nonionic surfactants (C12En n=3, 4, 5, 6, 7 and 8) on the aqueous solution of sodium dodecyl sulfate (SDS) in absence and presence of NaCl was examined using small-angle neutron scattering (SANS), dynamic light scattering (DLS), and viscosity measurements. Upon addition of C12En, micellar size of SDS was found to increase significantly, and such micellar elong...

Effects of trypsin and certain surface-active agents on meningo-pneumonitis virus and on normal chorio-allantoic membrane particulates.

TOXICOLOGICAL STUDIES ON CERTAIN AMINOALKYL ETHERS AS POTENTIAL LONG-ACTING LOCAL ANAESTHETICS

The acute intravenous toxicities of a selection of three potential long-acting local anaesthetics belonging to the series of2- phenoxyethyldialkylamine were determined in mice. Two of the compounds were tertiary amines and the third a quaternary ammonium derivative.The I.V. median lethal dose, (LDso) of one of the tertiary compounds, 21A [N, N- diethyl-2- (2,6- diisopropyl) ethyl amine hyd...

Effect of antituberculous calixarenes on phospholipase A2 susceptibility and on fusion of phospholipid bilayers.

Some homologous calixarenes or polyoxyethylene ethers that are known to suppress or enhance experimental tuberculous infection (depending on their polyoxyethylene chain lengths) were examined for their effects on phospholipid bilayers. The effect of these solutes is seen at 0.5-50p.p.m., and their effect depends upon their structure as well as that of the phospholipid substrate. The antitubercu...